Drug Options For Treatment Of Microsporum Canis

Discussion in 'Veterinary News' started by Admin, Jul 21, 2016.

By Admin on Jul 21, 2016 at 7:48 AM
  1. Admin

    Admin Administrator Staff Member

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    ITRACONAZOLE
    Dogs: 5 mg/kg PO once a day for 7 days, stop for 7 days; repeat pattern 3 times

    Cats: 5 mg/kg PO once a day for 7 days, stop for 7 days; repeat pattern 3 times

    Itraconazole, a fungistatic triazole, inhibits the cytochrome P450 enzyme lanosterol 14α-demethylase, which converts lanosterol to ergosterol.3 Decreases in ergosterol affect membrane permeability. Avoid alkalinizing agents (eg, H2-blockers, antacids).3 Alanine aminotransferase (ALT) and serum alkaline phosphatase (SAP) levels may rise without liver disease signs, though hepatotoxicity is rare.3

    Compounded itraconazole has produced low plasma concentrations in dogs and should be avoided.5

    In cats, the oral solution is preferred to capsules.4Generic and compounded itraconazole have not been shown to be bioequivalent to Sporanox.5Generic formulations have shown similar pharmacokinetic data; compounded itraconazole has produced low plasma concentrations in dogs and should be avoided.

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Discussion in 'Veterinary News' started by Admin, Jul 21, 2016.

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